Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet.
作者： Jie Qi , Bo Yang , Cailing Ren , Jian Fu , Jun Zhang
DOI: 10.1155/2016/1564386
关键词:
摘要: We aimed to investigate whether swimming exercise could improve insulin resistance (IR) by regulating tripartite motif family protein 72 (TRIM72) expression and AKT signal pathway in rats fed with high-fat diet. Five-week-old were classified into 3 groups: standard diet as control (CON), (HFD), HFD plus (Ex-HFD). After 8 weeks, glucose infusion rate (GIR), markers of oxidative stress, mRNA TRIM72, IRS, p-AKTSer473, determined quadriceps muscles. Compared HFD, the GIR, muscle SOD, GSH-Px significantly increased (p < 0.05, resp.), whereas MDA 8-OHdG levels decreased 0.05 p 0.01) Ex-HFD. Expression TRIM72 muscles reduced 0.01), IRS-1, Ex-HFD compared 0.01, 0.05). These results suggest that an 8-week improves HFD-induced maybe through a reduction skeletal enhancement transduction.
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