Association between panic disorder, major depressive disorder and celiac disease: A possible role of thyroid autoimmunity

摘要: Objective: To evaluate the association between celiac disease and specific anxiety depressive disorders to identify potential common pathogenetic links, with particular regard thyroid function autoimmunity. Methods: Cases included 36 adult patients, 25 females 11 males, aged 18–64 years. Controls comprised 144 healthy subjects matched by sex age no clinical evidence or family history of disease. Diagnosis was made on basis serological criteria. Psychiatric diagnoses were formulated using International Composite Diagnostic Interview, according DSM-IV Thyroid evaluated palpation, echography measurement serum-free hormones (FT4, FT3), thyroid-stimulating hormone (TSH) antithyroid autoantibodies (anti-TPO). Results: Compared controls, a significantly higher number patients met criteria for lifetime [15 (41.7%) versus 30 (29.8%), P<.01] 6-month [7 (19.4%) 9 (6.2%), OR=3.2, χ2=5.2, P<.05] major disorder (MDD) [5 (13.9%) 3 (2.1%), P<.001] [3 (8.1%) 2 (1.4%), panic (PD). Anti-TPO prevalence in than control group (11/36=30.5% 14/144=9.7%, P<.001). A frequency PD MDD found positive anti-TPO when compared negative (4/11=36.4% TPO+ 1/25=4% TPO−, P<.01; 9/11=81.8% MD 6/25=9.5% P<.01). Conclusion: Patients affected tend show high subclinical appears represent significant risk factor these psychiatric disorders.