Translation rate modification by preferential codon usage: intragenic position effects.
作者： Hans Liljenström , Gunnar von Heijne
DOI: 10.1016/S0022-5193(87)80251-5
关键词:
摘要: We present a model for calculating the protein production rate as function of translation rate. The takes into account that elongation along an mRNA molecule is non-uniform result different tRNA availabilities codons. Initiation ribosomes on normally rate-limiting step in process, and blocking initiation site can be avoided if codons closest to this allow fast by ribosome. Hence, selective forces may act choice synonymous region than elsewhere given mRNA. show whole influences abundant proteins, whereas only importance rare proteins. also analysis codon distribution known mRNAs coding
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