Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells
作者： D.G.A. Burton , H. Matsubara , K. Ikeda
DOI: 10.1016/J.EXGER.2010.07.005
关键词:
摘要: The accumulation of senescent cells within tissues can potentially lead to biological dysfunction and manifestation disease associated with ageing. majority display a commonly altered secretome similar wound healing response (termed the senescence-associated secretory phenotype or SASP), which could have deleterious implications on tissue microenvironment. However, also appear cell-type (or even cell-strain) exclusive (CESP), an area research that is underexplored. One such CESP pro-calcificatory recently reported in vascular smooth muscle (VSMCs). Senescent VSMCs been shown overexpress genes proteins (including RUNX-2, alkaline phosphatase (ALP), type I collagen BMP-2) osteoblasts, leading partial osteoblastic transdifferentiation. As such, it has suggested contribute cardiovascular through induction calcification. This review discusses recent findings VSMC senescence their potential role pathophysiology
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