Inherited Differences in Intensity of Alcohol Withdrawal Reactions in Mice

摘要: IT is not known whether alcoholism an inherited disease, although some aspects of this complex disorder have been shown to be genetically determined. One might expect that genetic factors could influence either the tendency individual drink excessively or sensitivity individuals effects a given alcohol intake, both. Most work has dealt with drinking behaviour. For example, it well inbred strains mice differ in voluntary intake1. In man, twin studies higher concordance monozygotic than dizygotic pairs respect patterns drinking2,3. Alcoholism frequent among offspring alcoholics, even when raised away from their biological parents4,5. Genetic differences acute mice6 and human populations (Caucasoid compared Mongoloid)7. I report here genes severity withdrawal mice. This may mean vulnerability physical dependence can inherited.