AN ANIMAL MODEL FOR TESTING EFFECTS OF DRUGS ON ALCOHOL WITHDRAWAL REACTIONS

摘要: Mice were made physically dependent on alcohol by three days of continuous intoxication, produced inhalation vapor. An inhibitor metabolism was used to stabilize blood levels. The severity the ensuing withdrawal reaction assessed quantitatively scoring intensity convulsions elicited lifting mice. Several drugs suppressed when it already under way. Effective included ethanol, barbiturates and benzodiazepines. No beneficial effect followed administration phenothiazines or chlormethiazole. Unexpectedly, some mice died during phase after treatment with long-acting (barbiturates benzodiazepines) that effectively convulsions.