Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain
作者： Clas Linnman , Lieuwe Appel , Tomas Furmark , Anne Söderlund , Torsten Gordh
DOI: 10.1016/J.PAIN.2010.01.008
关键词:
摘要: Neurokinin 1 (NK1) receptors are involved in pain and anxiety behaviors animals, but little is known about central alterations this receptor system human pain. With positron emission tomography, using a [11]-Carbon labeled NK1 antagonist, we demonstrate attenuated availability frontal, insular cingulate cortex, as well the hippocampus, amygdala periaqueductal gray area patients with chronic The reduced was most pronounced ventromedial prefrontal cortex (vmPFC), where attenuations correlated to measures of fear avoidance movement. Further, vmPFC levels also displayed opposing influences compared controls on regional cerebral blood flow anterior cingulate. We conclude that altered results suggest modulate motor inhibition, contribute
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sci-hub.se 参考文章(59)
Charles D. Spielberger, Richard L. Gorsuch, R. E. Lushene, Manual for the State-Trait Anxiety Inventory Consulting Psychologist. ,(1970)
SN Haber, K Kunishio, M Mizobuchi, E Lynd-Balta, The orbital and medial prefrontal circuit through the primate basal ganglia The Journal of Neuroscience. ,vol. 15, pp. 4851- 4867 ,(1995) , 10.1523/JNEUROSCI.15-07-04851.1995
S.T. Carmichael, J.L. Price, Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys The Journal of Comparative Neurology. ,vol. 371, pp. 179- 207 ,(1996) , 10.1002/(SICI)1096-9861(19960722)371:2<179::AID-CNE1>3.0.CO;2-#
E.J.C.M Swinkels-Meewisse, R.A.H.M Swinkels, A.L.M Verbeek, J.W.S Vlaeyen, R.A.B Oostendorp, Psychometric properties of the Tampa Scale for kinesiophobia and the fear-avoidance beliefs questionnaire in acute low back pain. Manual Therapy. ,vol. 8, pp. 29- 36 ,(2003) , 10.1054/MATH.2002.0484
Åsa Michelgård, Lieuwe Appel, Anna Pissiota, Örjan Frans, Bengt Långström, Mats Bergström, Mats Fredrikson, Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system. Biological Psychiatry. ,vol. 61, pp. 1002- 1006 ,(2007) , 10.1016/J.BIOPSYCH.2006.07.003
Ray Hill, None, NK1 (substance P) receptor antagonists – why are they not analgesic in humans? Trends in Pharmacological Sciences. ,vol. 21, pp. 244- 246 ,(2000) , 10.1016/S0165-6147(00)01502-9
Henning Vaerøy, Robert Helle, Øystein Førre, Erik Kåss, Lars Terenius, Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis. Pain. ,vol. 32, pp. 21- 26 ,(1988) , 10.1016/0304-3959(88)90019-X
E. Kafetzopoulos, M.-S. Holzh�uer, J.P. Huston, Substance P injected into the region of the nucleus basalis magnocellularis facilitates performance of an inhibitory avoidance task Psychopharmacology. ,vol. 90, pp. 281- 283 ,(1986) , 10.1007/BF00181260
Mohammed R. Milad, Gregory J. Quirk, Neurons in medial prefrontal cortex signal memory for fear extinction Nature. ,vol. 420, pp. 70- 74 ,(2002) , 10.1038/NATURE01138
P.J. Elliott, S.D. Iversen, Behavioural effects of tachykinins and related peptides. Brain Research. ,vol. 381, pp. 68- 76 ,(1986) , 10.1016/0006-8993(86)90691-8