Local and Systemic Expression of Immunomodulatory Factors in Chronic Pancreatitis

摘要: Inflammatory and fibrotic events that drive chronic pancreatitis (CP) are likely orchestrated via signaling of soluble cytokines chemokines systemically within the pancreas. However, a comprehensive summary expression such factors during CP has not been reported to date. This information is important given continued interest in targeting influence pathogenesis. Reported data on change immunomodulatory human patients were identified literature search using single term. Thirty-one articles meeting prespecified inclusion criteria generate compiled summary. Compiled demonstrated up-regulation several blood or pancreas microenvironment patients. Nine elevated both compartments, including fractalkine, IFN-γ, interleukin 1β, IL-6, IL-8, macrophage inhibitory cytokine 1, neutrophil gelatinase-associated lipocalin, transforming growth factor β, tumor necrosis α. Most up-regulated could be classified into one functional groups, inflammation, chemotaxis, angiogenesis, bone remodeling, extracellular matrix pain. After further validation, these may used as biomarkers for disease diagnosis identification comorbidities, potential therapeutic targets.