Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
作者： J. B. Swann , M. D. Vesely , A. Silva , J. Sharkey , S. Akira
关键词:
摘要: Here we report the effects of loss Toll-like receptor-associated signaling adaptor myeloid-differentiation factor 88 (MyD88) on tumor induction in two distinct mouse models carcinogenesis. The 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin papilloma model depends proinflammatory processes, whereas 3′-methylcholanthrene (MCA) fibrosarcoma has been used by immunologists to illustrate innate and adaptive immune surveillance cancer. When exposed a combination DMBA/TPA, mice lacking MyD88 formed fewer papillomas than genetically matched WT controls treated similar manner. Unexpectedly, however, MyD88−/− sarcomas when MCA. In contrast, MyD88-deficient did not show defective ability reject highly immunogenic transplanted tumors, including MCA sarcomas. Despite reported role TNF chronic inflammation, TNF-deficient were significantly more susceptible MCA-induced sarcoma mice. Overall, these data only confirm key that plays promoting development but also demonstrate inflammation-induced carcinogenesis cancer immunoediting can indeed occur same model.
uq.edu.au
harvard.edu
jstor.org 参考文章(31)
Mark J. Smyth, Gavin P. Dunn, Robert D. Schreiber, Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity Advances in Immunology. ,vol. 90, pp. 1- 50 ,(2006) , 10.1016/S0065-2776(06)90001-7
Erika Cretney, Kazuyoshi Takeda, Hideo Yagita, Moira Glaccum, Jacques J. Peschon, Mark J. Smyth, Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice Journal of Immunology. ,vol. 168, pp. 1356- 1361 ,(2002) , 10.4049/JIMMUNOL.168.3.1356
Jeremy B. Swann, Yoshihiro Hayakawa, Nadeen Zerafa, Kathleen C. F. Sheehan, Bernadette Scott, Robert D. Schreiber, Paul Hertzog, Mark J. Smyth, Type I IFN contributes to NK cell homeostasis, activation, and antitumor function. Journal of Immunology. ,vol. 178, pp. 7540- 7549 ,(2007) , 10.4049/JIMMUNOL.178.12.7540
Stephen C. Robinson, Lisa M. Coussens, Soluble mediators of inflammation during tumor development. Advances in Cancer Research. ,vol. 93, pp. 159- 187 ,(2005) , 10.1016/S0065-230X(05)93005-4
Robert J. Moore, David M. Owens, Gordon Stamp, Caroline Arnott, Frances Burke, Nick East, Hazel Holdsworth, Lynn Turner, Barrett Rollins, Manolis Pasparakis, George Kollias, Frances Balkwill, Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nature Medicine. ,vol. 5, pp. 828- 831 ,(1999) , 10.1038/10552
Vijay Shankaran, Hiroaki Ikeda, Allen T. Bruce, J. Michael White, Paul E. Swanson, Lloyd J. Old, Robert D. Schreiber, IFNγ, and lymphocytes prevent primary tumour development and shape tumour immunogenicity Nature. ,vol. 410, pp. 1107- 1111 ,(2001) , 10.1038/35074122
Joseph A. Hollenbaugh, Richard W. Dutton, IFN-γ Regulates Donor CD8 T Cell Expansion, Migration, and Leads to Apoptosis of Cells of a Solid Tumor The Journal of Immunology. ,vol. 177, pp. 3004- 3011 ,(2006) , 10.4049/JIMMUNOL.177.5.3004
Chenlu Malluck, Krystyna Frenkel, Jonathan Eckard, Xiaolu Li, Rajendra Shah, Interleukin-1α Up-Regulation in Vivo by a Potent Carcinogen 7,12-Dimethylbenz(a)anthracene (DMBA) and Control of DMBA-induced Inflammatory Responses Cancer Research. ,vol. 62, pp. 417- 423 ,(2002)
M. Girardi, Regulation of Cutaneous Malignancy by gamma delta T Cells Science. ,vol. 294, pp. 605- 609 ,(2001) , 10.1126/SCIENCE.1063916
Mark J. Smyth, Masaru Taniguchi, Shayna E. A. Street, The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent Journal of Immunology. ,vol. 165, pp. 2665- 2670 ,(2000) , 10.4049/JIMMUNOL.165.5.2665