The role of RNA-binding protein tristetraprolin in cancer and immunity.

摘要: RNA-binding protein tristetraprolin (TTP) plays a fundamental role in various physiological and pathological processes including differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis immunity. Due to its ability bind target ARE-containing mRNAs for rapid degradation, TTP down-regulates the expression of mass critical genes, thereby functioning as cancer suppressor gene. The loss has been reported several human cancers is relevant poor prognosis. Recent research shows that also an emerging significant aim this paper provide overview roles We summarize deficiency discuss lack can influence tumor progression at different aspects such promoting cell proliferation; accelerating cycle; improving survivability resisting death; inducing angiogenesis; activating invasion metastasis; epithelial-mesenchymal transition; deregulating cellular energetics. pay attention novel understanding relationship between Finally, due vital role, disorder both immune cells receives increasing we current thinking about regulatory mechanisms itself expression. This knowledge may contribute becoming diagnostic marker or immune-related diseases possible therapeutic target.