Vasoactive intestinal peptide alleviates food allergy via restoring regulatory B cell functions.
作者： Hao-Tao Zeng , Miao Zhao , Shao-Bo Yang , Huang Huang , Xiao-Rui Geng
DOI: 10.1016/J.IMBIO.2019.08.006
关键词:
摘要: The immune regulatory cell dysfunction is associated with many diseases including food allergy (FA). This study aims to investigate the role of vasoactive intestinal peptide (VIP) in maintenance B (Br cell)'s suppressive functions by stabilizing thrombospondin (TSP1) expression. In this study, blood samples were collected from patients (FA) and healthy control (HC) subjects. Br cells isolated through flow cytometry sorting analyzed immunological approaches determine capacity. We found that impaired FA patients. serum VIP levels production function-related mediators (interleukin-10, IL-10) counteracted IL-10 mRNA decay up regulating TSP1 inhibited tristetraprolin (TTP) prevent cells. Administration response restoration conclusion, administration can alleviate expression stabilize recover functions. results have translational potential for treatment other disorders
sci-hub.se 参考文章(35)
Xudong Li, Ye Zheng, Regulatory T cell identity: formation and maintenance. Trends in Immunology. ,vol. 36, pp. 344- 353 ,(2015) , 10.1016/J.IT.2015.04.006
Daniel Paparini, Esteban Grasso, Guillermina Calo, Daiana Vota, Vanesa Hauk, Rosanna Ramhorst, Claudia Pérez Leirós, Trophoblast cells primed with vasoactive intestinal peptide enhance monocyte migration and apoptotic cell clearance through αvβ3 integrin portal formation in a model of maternal-placental interaction. Molecular Human Reproduction. ,vol. 21, pp. 930- 941 ,(2015) , 10.1093/MOLEHR/GAV059
Gui Yang, Xiao-Rui Geng, Zhi-Qiang Liu, Jiang-Qi Liu, Xiao-Yu Liu, Ling-Zhi Xu, Huan-Ping Zhang, Ying-Xue Sun, Zhi-Gang Liu, Ping-Chang Yang, Thrombospondin-1 (TSP1)-producing B Cells Restore Antigen (Ag)-specific Immune Tolerance in an Allergic Environment Journal of Biological Chemistry. ,vol. 290, pp. 12858- 12867 ,(2015) , 10.1074/JBC.M114.623421
Jae Ho Lee, Joonyong Noh, Geunwoong Noh, Hyuk Soon Kim, Se Hwan Mun, Wahn Soo Choi, Sunheui Cho, Sangsun Lee, Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis. Cellular Immunology. ,vol. 262, pp. 44- 51 ,(2010) , 10.1016/J.CELLIMM.2009.12.006
Willem van de Veen, Barbara Stanic, Görkem Yaman, Marcin Wawrzyniak, Stefan Söllner, Deniz G. Akdis, Beate Rückert, Cezmi A. Akdis, Mübeccel Akdis, IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses Journal of Allergy and Clinical Immunology. ,vol. 131, pp. 1204- 1212 ,(2013) , 10.1016/J.JACI.2013.01.014
Rosa Bacchetta, Eleonora Gambineri, Maria-Grazia Roncarolo, Role of regulatory T cells and FOXP3 in human diseases. The Journal of Allergy and Clinical Immunology. ,vol. 120, pp. 227- 235 ,(2007) , 10.1016/J.JACI.2007.06.023
Huan-Ping Zhang, Yingying Wu, Jiangqi Liu, Jing Jiang, Xiao-Rui Geng, Gui Yang, Lihua Mo, Zhi-Qiang Liu, Zhi-Gang Liu, Ping-Chang Yang, None, TSP1-producing B cells show immune regulatory property and suppress allergy-related mucosal inflammation. Scientific Reports. ,vol. 3, pp. 3345- 3345 ,(2013) , 10.1038/SREP03345
Iria V Seoane, Eva Tomero, Carmen Martínez, Rosario Garcia-Vicuña, Yasmina Juarranz, Amalia Lamana, Elena Ocón, Ana M Ortiz, Nieves Gómez-León, Isidoro González-Álvaro, Rosa P Gomariz, None, Vasoactive Intestinal Peptide in Early Spondyloarthritis: Low Serum Levels as a Potential Biomarker for Disease Severity Journal of Molecular Neuroscience. ,vol. 56, pp. 577- 584 ,(2015) , 10.1007/S12031-015-0517-6
Seth A. Brooks, Perry J. Blackshear, Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. ,vol. 1829, pp. 666- 679 ,(2013) , 10.1016/J.BBAGRM.2013.02.003
Andrea Resovi, Denise Pinessi, Giovanna Chiorino, Giulia Taraboletti, Current understanding of the thrombospondin-1 interactome. Matrix Biology. ,vol. 37, pp. 83- 91 ,(2014) , 10.1016/J.MATBIO.2014.01.012