Biodegradable nanoparticles for improved kidney bioavailability of rhein: preparation, characterization, plasma, and kidney pharmacokinetics.
作者： Yinghui Wei , Xiaoting Luo , Jiani Guan , Jianping Ma , Yicong Zhong
DOI: 10.1080/03639045.2017.1353519
关键词:
摘要: AbstractThe aim of this work is to develop biodegradable nanoparticles for improved kidney bioavailability rhein (RH). RH-loaded were prepared using an emulsification solvent evaporation method and fully characterized by several techniques. Kidney pharmacokinetics was assessed implanting a microdialysis probe in rat's cortex. Blood samples simultaneously collected (via femoral artery) assessing plasma pharmacokinetics. Optimized small, with mean particle size 132.6 ± 5.95 nm, homogeneously dispersed. The charge on the particles nearly zero, encapsulation efficiency 62.71 ± 3.02%, drug loading 1.56 ± 0.15%. In vitro release RH from showed initial burst followed sustained release. Plasma that into significantly increased its (AUCkidney/AUCplasma = 0.586 ± 0.072), clearly indicating nanopar...
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