Expression alterations define unique molecular characteristics of spinal ependymomas

摘要: // Anbarasu Lourdusamy 1 , Ruman Rahman and Richard G. Grundy Children’s Brain Tumour Research Centre, School of Medicine, Queen’s Medical Centre University Nottingham, UK Correspondence to: Lourdusamy, email: Keywords : ependymoma; gene expression; meta-analysis; co-expression network Received February 20, 2015 Accepted March 11, Published 30, Abstract Ependymomas are glial tumors that originate in either intracranial or spinal regions. Although from different regions histologically similar, they biologically distinct. We therefore sought to identify molecular characteristics ependymomas (SEPN) order better understand the disease biology these tumors. Using expression profiles 256 tumor samples, we identified increased 1,866 genes SEPN when compared ependymomas. These mainly related anterior/posterior pattern specification, response oxidative stress, cell differentiation, DNA repair, PPAR signalling, also significantly enriched with cellular senescence (P = 5.5 × 10 -03 ). In addition, a high number down-regulated localized chromosome 22 (81 chr22: 43,325,255 – 135,720,974; FDR 1.77 -23 324,739 32,822,302; 2.07 -09 ) including BRD1, EP300, HDAC10, HIRA, HIC2, MKL1 NF2 . Evaluation co-expressed further confirms enrichment Finally, systematic integration interactome data identifies key candidate genes. Our results reveal unique such as altered