Influence of boost radiotherapy in patients with ductal carcinoma in situ breast cancer: a multicenter, retrospective study in Korea (KROG 11-04).
作者： Jin Hee Kim , Doo Ho Choi , Won Park , Seung Do Ahn , Su Ssan Kim
DOI: 10.1007/S10549-014-3025-4
关键词:
摘要: To estimate the effect of boost radiotherapy on local recurrence-free survival (LRFS) in patients with ductal carcinoma situ (DCIS) breast cancer. We included from nine institutions who met following criteria: having Tis, age 18 years or older, conserving surgery (BCS) and within 12 weeks after surgery. From 1995 through 2006, 728 were analyzed retrospectively by Korean Radiation Oncology Group. All received whole-breast radiation therapy (WBRT) BCS. 232 (31.9 %) also (RT) (median 10 Gy). After median follow-up 82 months, 5-year LRFS was 98.4 % 10-year 95.8 for all patients. There no statistically significant difference between no-boost groups. Nineteen (2.6 had ipsilateral recurrences, including invasive recurrence 7 DCIS. The presence HER2 receptor associated more recurrences. Nine (1.2 developed contralateral cancer, six cancer three In multivariate analysis, only margin status a prognostic factor LRFS. Boost RT not further improvement control DCIS BCS WBRT. receptor-positive may need treatment anti-HER2 agents.
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Sulkes J, Rizel S, Gutman H, Dinerman M, Neumann A, Yarom N, Yerushalmi R, Sulkes A, Mishaeli M, Fenig E, Radiation treatment for ductal carcinoma in situ (DCIS): is a boost to the tumor bed necessary? Neoplasma. ,vol. 53, pp. 507- 510 ,(2006)
Amélie Monteau, Brigitte Sigal-Zafrani, Youlia M. Kirova, Virginie Fourchotte, Marc A. Bollet, Anne Vincent-Salomon, Bernard Asselain, Remy J. Salmon, Alain Fourquet, Ductal carcinoma in situ of the breast with close or focally involved margins following breast-conserving surgery: treatment with reexcision or radiotherapy with increased dosage. International Journal of Radiation Oncology Biology Physics. ,vol. 75, pp. 1021- 1028 ,(2009) , 10.1016/J.IJROBP.2008.12.014
G.F. Schwartz, L.J. Solin, I.A. Olivotto, V.L. Ernster, P. Pressman, The Consensus Conference on the Treatment of in situ Ductal Carcinoma of the Breast, 22-25 April 1999. The Breast. ,vol. 9, pp. 177- 186 ,(2000) , 10.1054/BRST.1999.0156
X-F Wen, G Yang, W Mao, A Thornton, J Liu, R C Bast, X-F Le, HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: Implications for HER2-targeted antibody therapy Oncogene. ,vol. 25, pp. 6986- 6996 ,(2006) , 10.1038/SJ.ONC.1209685
Olivier Riou, Claire Lemanski, Vanessa Guillaumon, Olivier Lauche, Pascal Fenoglietto, Jean-Bernard Dubois, David Azria, Role of the Radiotherapy Boost on Local Control in Ductal Carcinoma In Situ International Journal of Surgical Oncology. ,vol. 2012, pp. 748196- 748196 ,(2012) , 10.1155/2012/748196
AD Baildam, NJ Bundred, PA Holland, A Gandhi, WF Knox, M Wilson, The importance of complete excision in the prevention of local recurrence of ductal carcinoma in situ. British Journal of Cancer. ,vol. 77, pp. 110- 114 ,(1998) , 10.1038/BJC.1998.17
Lara Hathout, Tarek Hijal, Valérie Théberge, Bernard Fortin, Horia Vulpe, Jean-Charles Hogue, Christine Lambert, Houda Bahig, Louise Provencher, Peter Vavassis, Michael Yassa, Hypofractionated Radiation Therapy for Breast Ductal Carcinoma In Situ International Journal of Radiation Oncology Biology Physics. ,vol. 87, pp. 1058- 1063 ,(2013) , 10.1016/J.IJROBP.2013.08.026
Gunter von Minckwitz, Silvia Darb-Esfahani, Sibylle Loibl, Jens Huober, Hans Tesch, Christine Solbach, Frank Holms, Holger Eidtmann, Klaus Dietrich, Marianne Just, Michael R. Clemens, Claus Hanusch, Iris Schrader, Stephan Henschen, Gerald Hoffmann, Katharina Tiemann, Kurt Diebold, Michael Untch, Carsten Denkert, Responsiveness of adjacent ductal carcinoma in situ and changes in HER2 status after neoadjuvant chemotherapy/trastuzumab treatment in early breast cancer—results from the GeparQuattro study (GBG 40) Breast Cancer Research and Treatment. ,vol. 132, pp. 863- 870 ,(2012) , 10.1007/S10549-011-1621-0
Stefan O. Emdin, Bengt Granstrand, Anita Ringberg, Kerstin Sandelin, Lars-Gunnar Arnesson, Hans Nordgren, Harald Anderson, Hans Garmo, Lars Holmberg, Arne Wallgren, , SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening Acta Oncologica. ,vol. 45, pp. 536- 543 ,(2006) , 10.1080/02841860600681569
Yu Jin Lim, Kyubo Kim, Eui Kyu Chie, Wonshik Han, Dong Young Noh, Sung W. Ha, Treatment outcome of ductal carcinomain situpatients treated with postoperative radiation therapy Radiation Oncology Journal. ,vol. 32, pp. 1- 6 ,(2014) , 10.3857/ROJ.2014.32.1.1