Cancer metastasis determined by carbohydrate-mediated cell adhesion.
作者： Tatsuro Irimura
DOI: 10.1007/978-1-4615-2443-4_4
关键词:
摘要: During the progression of cancer to advanced stages, highly malignant and metastatic tumor cells are thought arise within primary tumors become predominant. On basis this hypothesis, surgical specimens from patients at various clinical stages colorectal carcinomas were compared for a variety molecular phenotypes possibly related metastasis. As result, with increased potential poor prognosis have been characterized by expression sialyl-LeX antigens. Human colon carcinoma cell lines selected their high or low antigens on surfaces. These differ in behavior nude mice. The expresser strongly adhere activated endothelial vitro. Retrospective studies immunohistochemical technique revealed that these molecules could be used as predictive marker
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