Prognostic Factors and Survival

摘要: The histological hallmark of primary Sjogren’s syndrome (pSS) is the focal lymphocytic infiltrates that slowly and steadily replace epithelium salivary lacrimal glands produce exocrine gland dysfunction, manifested mainly by xerostomia xerophthalmia [1]. These two clinical manifestations are determinants for term “exocrinopathy” in SS. Studies last 20 years have delineated type spectrum other organ involvement Lungs, liver kidneys usually affected pSS. histology evolution lesion above parenchymal tissues do not differ from observed glands. extragrandular mild severity most cases, evolve slowly, appear to respond glucocorticoids or immunosuppressive agents. central role epithelial cell as main target immune injury well lungs, has led introduction “autoimmune epithelitis”