Connections between TET proteins and aberrant DNA modification in cancer
作者： Yun Huang , Anjana Rao
DOI: 10.1016/J.TIG.2014.07.005
关键词:
摘要: DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer, and an imbalance methylation–demethylation cycles is intimately implicated the onset progression tumors. Ten-eleven translocation (TET) proteins are Fe(II)- 2-oxoglutarate (2OG)-dependent dioxygenases that successively oxidize 5-methylcytosine (5mC) 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), 5-carboxylcytosine (5caC), thereby mediating active demethylation. In this review, we focus on pathophysiological role TET 5hmC cancer. We present overview loss-of-function mutations abnormal expression regulation hematological malignancies solid tumors, discuss potential prognostic value assessing levels cancer patients. also address crosstalk between two critical enzymes involved cell metabolism: O -linked β- N -acetylglucosamine transferase (OGT) isocitrate dehydrogenase (IDH). Lastly, therapeutic targeting
elsevier.com
sci-hub.se 参考文章(146)
Gabriella Ficz, Timothy A Hore, Fatima Santos, Heather J Lee, Wendy Dean, Julia Arand, Felix Krueger, David Oxley, Yu-Lee Paul, Jörn Walter, Simon J Cook, Simon Andrews, Miguel R Branco, Wolf Reik, FGF signalling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency Clinical Epigenetics. ,vol. 5, pp. 1- 1 ,(2013) , 10.1186/1868-7083-5-S1-S2
Véronique Gelsi-Boyer, Virginie Trouplin, Julien Roquain, José Adélaïde, Nadine Carbuccia, Benjamin Esterni, Pascal Finetti, Anne Murati, Christine Arnoulet, Hacène Zerazhi, Hacène Fezoui, Zoulika Tadrist, Meyer Nezri, Max Chaffanet, Marie-Joëlle Mozziconacci, Norbert Vey, Daniel Birnbaum, ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. British Journal of Haematology. ,vol. 151, pp. 365- 375 ,(2010) , 10.1111/J.1365-2141.2010.08381.X
Peter A. Jones, Stephen B. Baylin, The fundamental role of epigenetic events in cancer Nature Reviews Genetics. ,vol. 3, pp. 415- 428 ,(2002) , 10.1038/NRG816
Hidemasa Goto, Yoshihiro Yasui, Erich A. Nigg, Masaki Inagaki, Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes to Cells. ,vol. 7, pp. 11- 17 ,(2002) , 10.1046/J.1356-9597.2001.00498.X
Katarzyna J. Nytko, Nobuyo Maeda, Philipp Schläfli, Patrick Spielmann, Roland H. Wenger, Daniel P. Stiehl, Vitamin C is dispensable for oxygen sensing in vivo Blood. ,vol. 117, pp. 5485- 5493 ,(2011) , 10.1182/BLOOD-2010-09-307637
H Yang, Y Liu, F Bai, JY Zhang, SH Ma, J Liu, ZD Xu, HG Zhu, ZQ Ling, D Ye, KL Guan, Y Xiong, None, Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation Oncogene. ,vol. 32, pp. 663- 669 ,(2013) , 10.1038/ONC.2012.67
Teresa Palomero, Lucile Couronné, Hossein Khiabanian, Mi-Yeon Kim, Alberto Ambesi-Impiombato, Arianne Perez-Garcia, Zachary Carpenter, Francesco Abate, Maddalena Allegretta, J Erika Haydu, Xiaoyu Jiang, Izidore S Lossos, Concha Nicolas, Milagros Balbin, Christian Bastard, Govind Bhagat, Miguel A Piris, Elias Campo, Olivier A Bernard, Raul Rabadan, Adolfo A Ferrando, None, Recurrent mutations in epigenetic regulators, rhoa and fyn kinase in peripheral t-cell lymphomas Nature Genetics. ,vol. 46, pp. 166- 170 ,(2014) , 10.1038/NG.2873
Jozef Madzo, Hui Liu, Alexis Rodriguez, Aparna Vasanthakumar, Sriram Sundaravel, Donne Bennett D. Caces, Timothy J. Looney, Li Zhang, Janet B. Lepore, Trisha Macrae, Robert Duszynski, Alan H. Shih, Chun-Xiao Song, Miao Yu, Yiting Yu, Robert Grossman, Brigitte Raumann, Amit Verma, Chuan He, Ross L. Levine, Don Lavelle, Bruce T. Lahn, Amittha Wickrema, Lucy A. Godley, Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis Cell Reports. ,vol. 6, pp. 231- 244 ,(2014) , 10.1016/J.CELREP.2013.11.044
Jumpei Yamazaki, Rodolphe Taby, Aparna Vasanthakumar, Trisha Macrae, Kelly R. Ostler, Lanlan Shen, Hagop M. Kantarjian, Marcos R. Estecio, Jaroslav Jelinek, Lucy A. Godley, Jean-Pierre J. Issa, Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia Epigenetics. ,vol. 7, pp. 201- 207 ,(2012) , 10.4161/EPI.7.2.19015
Chih-Hung Hsu, Kai-Lin Peng, Ming-Lun Kang, Yi-Ren Chen, Yu-Chih Yang, Chin-Hsien Tsai, Chi-Shuen Chu, Yung-Ming Jeng, Yen-Ting Chen, Feng-Mao Lin, Hsien-Da Huang, Yun-Yuh Lu, Yu-Ching Teng, Shinn-Tsuen Lin, Ruo-Kai Lin, Fan-Mei Tang, Sung-Bau Lee, Huan Ming Hsu, Jyh-Cherng Yu, Pei-Wen Hsiao, Li-Jung Juan, TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases Cell Reports. ,vol. 2, pp. 568- 579 ,(2012) , 10.1016/J.CELREP.2012.08.030