Models for Tumour Cell Adhesion and Invasion

摘要: The prevention of death in most cancer patients is dependenton understanding the mechanisms cell spread fromthe primary tumour to distant organ sites. Although thepathogenesis metastasis subject numerous studiesin basic and clinical research, complex thatmake a metastatic are not well understood. Thedevelopment metastases non-random process, wherethe implantation, invasion, survival, growth singlecell or small numbers cells can lead morbidity anddeath.The sequential model for development metastasesinvolves growth, neovascularization, invasionat sites, followed by penetration into lym-phatic blood vessels body cavities. Malig-nant that loose cellular contacts with surroundingcells extracellular matrix (ECM) undergo pheno-typic change greater motility. Subsequently, malignantcells be released from dis-tributed throughout via lymphaticcirculation. To survive, circulating usu-ally have adhere vessel walls hostorgans, eventually penetrate wall avoid bloodshear forces. Finally, metastasizing survivethe host defence grow (Nicolson, 1988a,b)(see