Engineering a Cell Home for Stem Cell Homing and Accommodation.
作者： Rui-Xin Wu , Yuan Yin , Xiao-Tao He , Xuan Li , Fa-Ming Chen
关键词:
摘要: Distilling complexity to advance regenerative medicine from laboratory animals humans, in situ regeneration will continue evolve using biomaterial strategies drive endogenous cells within the human body for therapeutic purposes; this approach avoids need delivering ex vivo-expanded cellular materials. Ensuring recruitment of a significant number reparative an source site interest is first step toward achieving success. Subsequently, making "cell home" cell-friendly by recapitulating natural extracellular matrix (ECM) terms its chemistry, structure, dynamics, and function, targeting specific aspects native stem cell niche (e.g., cell-ECM cell-cell interactions) program steer fates those recruited play equally crucial roles yielding therapeutically solution. This review addresses key material-guided homing engineering novel biomaterials with desirable ECM composition, surface topography, biochemistry, mechanical properties that can present both biochemical physical cues required tissue regeneration. growing knowledge likely become design basis development for, but not limited to, future
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