Rapid Access to Synthetic Lysobisphosphatidic Acids Using PIII Chemistry
作者： Julien Chevallier , Naomi Sakai , Fabien Robert , Toshihide Kobayashi , Jean Gruenberg
DOI: 10.1021/OL0059246
关键词:
摘要: An expeditious route to synthetic lysobisphosphatidic acid S,S-1, its enantiomer, and regioisomers is reported. Synthetic difficulties concerning lipid stability stereochemistry are bypassed using a phosphite triester approach in combination with multiple silyl protection. Spectroscopic studies evidence that acyl group migration S,S-1 accelerated by nonpolar solvents inhibited pyridine.
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