Immunoglobulin A1 and A2 subclass of salivary antibodies to Candida albicans in patients with oral candidosis.

摘要: Immunoglobulin A antibody titres to a cytoplasmic protein extract of Candida albicans were determined by ELISA in saliva from 20 patients with oral candidosis and 21 controls. Patients had significantly increased levels salivary IgA anti-Candida antibodies when compared controls (P less than 0.001). Antibody associated IgA1 subclass 90% the patients; contrast, IgA2 was predominant 67% Antifungal therapy resulted decreased 0.05) whilst mean titre remained unchanged. The results indicate that infection may change pattern antibodies.