Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943)

摘要: Abstract Daunomycin (50 mg/kg) was lethal to Syrian golden hamsters ( 10 ) within 2–3 days, however, when this same dose given 30 min after 100 mg/kg of 2,6-piperazinedione, 4,4′-propylenedi-, [±]-(ICRF 159) half the animals 5 survived over 21 days. Between 40 and 51% total daunomycin could be recovered unchanged from hamster serum, urine, heart, lung, liver, kidney spleen. The amount these tissues higher (44–69%) in pretreated with ICRF 159. daunomycinone, a metabolite daunomycin, various less at all intervals 159 (0–3% dose) compared 4–9% saline-pretreated hamsters. iv administration rhesus monkey produced hyperglycemia (140%) 15 min, followed by secondary hypoglycemia 1–3 hr. Pretreatment (100 blocked initial increase, but not decrease, blood sugar 3-hr period. increased creatine phosphokinase glutamic-oxaloacetic transaminase serum enzyme activities 13 4.5 times, respectively. Smaller increases were detected glutamic-pyruvic (3.5 times) lactic acid dehydrogenase (2.5 times). attenuated In present experiments, decrease production daunomycinone may an important factor reduction toxicity.