Nausea and vomiting following thyroid and parathyroid surgery

摘要: Abstract Study Objectives: To determine the incidence of postoperative nausea and vomiting (PONV) following thyroid parathyroid surgery. whether PONV is reduced when propofol used for maintenance anesthesia as compared to isoflurane evaluate costs resource consumption associated with these two anesthetic regimens. Design: Randomized, prospective study. Setting: University-affiliated hospital—a referral center endocrinologic Patients: 118 ASA physical status I II patients, aged 18 years older, undergoing elective or Interventions: Patients received either (0.5 1.3% end-tidal) (50 200 μg/kg/min) anesthesia. All patients induction anesthesia, succinylcholine vecuronium, nitrous oxide, fentanyl. Prophylactic antiemetics were not administered. Postoperative pain was treated ketorolac, fentanyl, acetaminophen. Measurements Main Results: Signs symptoms graded on a four point scale 1=no nausea; 2=mild 3=severe 4=retching and/or vomiting. Grades 3 4 grouped together PONV. The combined 54% over 24-hour evaluation period. significantly more common in receiving than (64% vs. 44%). In women (n = 87), greater those who (71% 42%). However, men 31), there no significant difference between regimens (47% vs . 50% propofol). There differences duration stay postanesthesia care unit, time discharge from hospital, local wound complications (hematomas) groups. use an additional cost, relative group, $54.26 per patient. Conclusion: surgery are at high risk development Propofol although expensive isoflurane, reduces rate women.