The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario.

摘要: There is strong evidence from humans and animal models showing that abnormal functioning of the hypothalamic-pituitary-adrenal (HPA) axis and/or inflammatory response system disrupts feedback regulation both neuroendocrine immune systems, contributing to disease. Stress known affect physiology pelvic organs disturb HPA leading chronic, painful, disorders. A link between stress disease has already been documented for many chronic conditions. Endometriosis a complex gynecological associated with severe pain infertility affects 10% reproductive-aged women. Patients report negative impact endometriosis symptoms on quality life, work/study productivity, personal relationships, which in turn cause high levels psychological emotional distress. The relationship not clear. Still, we have recently demonstrated increases size severity lesions as well parameters an model. Furthermore, “controllability” influences pathophysiology this model, offering possibility using management techniques patients. crosstalk stress-inflammation-pain through activity indicates relief should alleviate inflammation and, turn, decrease painful responses. This opens up opportunity altering brain-body-brain pathways potential new therapeutic option endometriosis. goal review gather research regarding interaction (psychological physiological) development progression exacerbation its purpose proposing lines emerging possible treatment modalities still incurable