Genetic variation in the response to vaccination.

摘要: Vaccines are the most powerful means to prevent and diminish burden of infectious disease. However, there limitations their use: vaccines not yet available for all diseases (including human immunodeficiency virus respiratory syncytial virus), they sometimes lack efficacy, response vaccination is limited by maternal antibodies in very young infants, variable or may even be absent some individuals. This review focuses on genetic factors that determine vaccination. The highly polymorphic leukocyte antigen system, which involved presentation, has been researched this aspect, clearly affects Other, but less pathways Toll-like receptor pathway, recognition stimulation immune cytokine immunoregulatory network. heritability, proportion total variance due additive factors, appears particularly large vaccine-induced antibody responses infants compared with cell-mediated older, immunologically more mature Both only affected loci within, also strongly outside system. Because genes important influencing still unknown, work required. A better understanding an effective lead identification specific as targets development novel uniformly vaccines.