Genomics of immune response to typhoid and cholera vaccines.

摘要: Considerable variation in antibody response (AR) was observed among recipients of an injectable typhoid vaccine and oral cholera vaccine. We sought to find whether polymorphisms genes the immune system, both innate adaptive, were associated with response. For vaccines, we able discover validate several that significantly these on belonged pathways polysaccharide recognition, signal transduction, inhibition T-cell proliferation, pro-inflammatory signalling eventual production antimicrobial peptides. vaccine, included epithelial barrier integrity, intestinal homeostasis leucocyte recruitment. Even though traditional wisdom indicates vaccines should act as T-cell-independent antigens, our findings reveal induce AR using different pathways.