The association between antimicrobial resistance and HIV infection: a systematic review and meta-analysis

摘要: Abstract Objectives People living with HIV (PLWH) are at increased risk of infections resistant organisms due to more frequent healthcare utilization. Our objective was investigate the association between and antimicrobial resistance (AMR). Methods We searched MEDLINE, EMBASE, Web Science, LILACS African Journals Online. Studies were eligible if they reported on AMR for colonization or infection bacterial pathogens (excluding mycobacteria bacteria causing sexually transmitted infections) stratified by status, species antimicrobials tested. Pooled odds ratios used evaluate resistance. Results In total, 92 studies published 1995 2020 identified. The included following organisms: Staphylococcus aureus (n = 47), Streptococcus pneumoniae (n = 28), Escherichia coli (n = 6) other Gram-negative bacteria. PLWH had a 2.12 (95%CI 1.36–3.30) higher 1.90 1.45–2.48) methicillin-resistant S. aureus, 2.28 1.75–2.97) S. pneumoniae decreased penicillin susceptibility, 1.59 0.83-3.05) third-generation cephalosporins in E. coli Klebsiella pneumoniae. Conclusion This review shows an across range multiple drug classes. lack laboratory capacity identifying AMR, limited access alternative treatment options countries highest burden HIV, highlight need research PLWH. Overall, quality moderate low, which may impact findings this review.