Dilemmas and choices in infection management of the cancer patient

作者: Stephen C. Schimpff

DOI: 10.1016/0277-5379(89)90086-2

关键词:

摘要: Dilemmas related to fever and infection in the granulocytopenic cancer patient demand management choices frequently face of inadequate data assure confidence decision taken. Key elements decision-making include: recognition types infections which tend occur these patients within one's own institution usual antimicrobial susceptibility patterns common pathogens institution. Second, one must differentiate moderately from likely have profound, persistent granulocytopenia and, hence, a high risk mortality gram-negative rod bacteremia. This information will assist selection an initial empiric regimen. The same conjunction with results surveillance cultures especially repeat daily history physical examination decisions discontinuation antibiotics, alterations original regimen, possible superinfections.

参考文章(17)
Gary E. Ruoff, The pain of osteoarthritis. The American Journal of Medicine. ,vol. 80, pp. 96- 100 ,(1986) , 10.1016/0002-9343(86)90121-X
D. M. Hahn, S. C. Schimpff, C. L. Fortner, A. C. Smyth, V. M. Young, P. H. Wiernik, Infection in Acute Leukemia Patients Receiving Oral Nonabsorbable Antibiotics Antimicrobial Agents and Chemotherapy. ,vol. 13, pp. 958- 964 ,(1978) , 10.1128/AAC.13.6.958
Drew J. Winston, Robert C. Barnes, Winston G. Ho, Lowell S. Young, Richard E. Champlin, Robert P. Gale, Moxalactam plus piperacillin versus moxalactam plus amikacin in febrile granulocytopenic patients The American Journal of Medicine. ,vol. 77, pp. 442- 450 ,(1984) , 10.1016/0002-9343(84)90100-1
JAMES C WADE, STEPHEN C SCHIMPFF, KATHRYN A NEWMAN, PETER H WIERNIK, Staphylococcus epidermidis: An Increasing Cause of Infection in Patients with Granulocytopenia Annals of Internal Medicine. ,vol. 97, pp. 503- 508 ,(1982) , 10.7326/0003-4819-97-4-503
D. van der Waaij, J. M. Berghuis, J. E. C. Lekkerkerk, Colonization resistance of the digestive tract of mice during systemic antibiotic treatment. Journal of Hygiene. ,vol. 70, pp. 605- 610 ,(1972) , 10.1017/S0022172400022464
M.P. Glauser, Immunotherapy of gram-negative infections in oncological patients. European Journal of Cancer and Clinical Oncology. ,vol. 25, pp. 1359- 1364 ,(1989) , 10.1016/0277-5379(89)90087-4
Jerry L. Shenep, Walter T. Hughes, Paula K. Roberson, Kolleen R. Blankenship, Donald K. Baker, William H. Meyer, Francis Gigliotti, John W. Sixbey, Victor M. Santana, Sandor Feldman, Lennie Lott, Vancomycin, Ticarcillin, and Amikacin Compared with Ticarcillin-Clavulanate and Amikacin in the Empirical Treatment of Febrile, Neutropenic Children with Cancer New England Journal of Medicine. ,vol. 319, pp. 1053- 1058 ,(1988) , 10.1056/NEJM198810203191604
Philip A. Pizzo, K.J. Robichaud, Fred A. Gill, Frank G. Witebsky, Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia The American Journal of Medicine. ,vol. 72, pp. 101- 111 ,(1982) , 10.1016/0002-9343(82)90594-0
J Klastersky, M P Glauser, S C Schimpff, S H Zinner, H Gaya, Prospective randomized comparison of three antibiotic regimens for empirical therapy of suspected bacteremic infection in febrile granulocytopenic patients. Antimicrobial Agents and Chemotherapy. ,vol. 29, pp. 263- 270 ,(1986) , 10.1128/AAC.29.2.263