Comprehensive analysis of genomic alterations, clinical outcomes, putative functions and potential therapeutic value of MMP11 in human breast cancer
作者： Amritha Sathyanarayanan , Aparna Natarajan , Oviya Revathi Paramasivam , Prarthana Gopinath , Gopisetty Gopal
DOI: 10.1016/J.GENREP.2020.100852
关键词:
摘要: Abstract The aim of the current study is to comprehend prognostic and therapeutic value matrix metalloproteinase (MMP11) in breast cancer using computational analyses. Gene expression-based Outcome for Breast Online (GOBO) analysis revealed that MMP11 expression was increased tumor when compared normal. Among subtypes, human epidermal growth factor receptor 2 (HER2) enriched estrogen (ER) positive showed higher MMP11. results were independently validated with cBioPortal Oncomine databases. Tumors high poor overall survival distant metastasis free survival. Further, protein-protein interactome network constructed molecular pathway Reactome database identified its putative role diverse cellular processes. In addition, UALCAN web portal hypomethylation promoter region tumors. Molecular docking iGEMDOCK Autodock Vina performed identify natural compounds repurposed drugs interaction Our confirms significance their intrinsic subtypes. Twelve bio-compounds which predominantly flavonoids anti-psychotic drug pimozide significant scores potential these inhibiting related pathways targeting cells are yet be studied.
sci-hub.st 参考文章(101)
Elin Hadler-Olsen, Bodil Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen, Jan-Olof Winberg, Regulation of matrix metalloproteinase activity in health and disease FEBS Journal. ,vol. 278, pp. 28- 45 ,(2011) , 10.1111/J.1742-4658.2010.07920.X
Andras Jeney, Revekka Harisi, Extracellular matrix as target for antitumor therapy. OncoTargets and Therapy. ,vol. 8, pp. 1387- 1398 ,(2015) , 10.2147/OTT.S48883
Jia-Jie Chen, Nan Cai, Guan-Zhong Chen, Chang-Chang Jia, Dong-Bo Qiu, Cong Du, Wei Liu, Yang Yang, Zi-Jie Long, Qi Zhang, The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma Oncotarget. ,vol. 8, pp. 17593- 17609 ,(2017) , 10.18632/ONCOTARGET.4307
Jinqi Xue, Zhiguang Chen, Xi Gu, Yang Zhang, Wenhai Zhang, MicroRNA-148a inhibits migration of breast cancer cells by targeting MMP-13. Tumor Biology. ,vol. 37, pp. 1581- 1590 ,(2016) , 10.1007/S13277-015-3926-9
Dmitri Mouradov, Oliver M. Sieber, Richard J. Simpson, Agus Salim, Antony Bacic, Andrew F. Hill, David A. Stroud, Michael T. Ryan, Johnson I. Agbinya, John M. Mariadason, Antony W. Burgess, Suresh Mathivanan, Mohashin Pathan, Shivakumar Keerthikumar, Ching-Seng Ang, Lahiru Gangoda, Camelia Y.J. Quek, Nicholas A. Williamson, FunRich: An open access standalone functional enrichment and interaction network analysis tool PROTEOMICS. ,vol. 15, pp. 2597- 2601 ,(2015) , 10.1002/PMIC.201400515
Mina M. Benjamin, Raouf A. Khalil, Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease Experientia. Supplementum. ,vol. 103, pp. 209- 279 ,(2012) , 10.1007/978-3-0348-0364-9_7
Ozlem Yersal, Biological subtypes of breast cancer: Prognostic and therapeutic implications. World journal of clinical oncology. ,vol. 5, pp. 412- 424 ,(2014) , 10.5306/WJCO.V5.I3.412
R.N. Williams, S.L. Parsons, T.M. Morris, B.J. Rowlands, S.A. Watson, Inhibition of matrix metalloproteinase activity and growth of gastric adenocarcinoma cells by an angiotensin converting enzyme inhibitor in in vitro and murine models. Ejso. ,vol. 31, pp. 1042- 1050 ,(2005) , 10.1016/J.EJSO.2005.04.003
Kyueng-Whan Min, Dong-Hoon Kim, Sung-Im Do, Jung-Soo Pyo, Kyungeun Kim, Seoung Wan Chae, Jin Hee Sohn, Young-Ha Oh, Hong Joo Kim, Seon Hyeong Choi, Yoon Jung Choi, Chan Heun Park, None, Diagnostic and Prognostic Relevance of MMP-11 Expression in the Stromal Fibroblast-Like Cells Adjacent to Invasive Ductal Carcinoma of the Breast Annals of Surgical Oncology. ,vol. 20, pp. 433- 442 ,(2013) , 10.1245/S10434-012-2734-3
Jeannine S. Strobl, Zaroui Melkoumian, Virginia A. Peterson, Heather Hylton, The cell death response to γ-radiation in MCF-7 cells is enhanced by a neuroleptic drug, pimozide Breast Cancer Research and Treatment. ,vol. 51, pp. 83- 95 ,(1998) , 10.1023/A:1006046604062