New technologies in drug metabolism and toxicity screening: organ-to-organ interaction.
作者： Abhinav Bhushan , Nicole J. Martucci , O. Berk Usta , Martin L. Yarmush
DOI: 10.1517/17425255.2016.1162292
关键词:
摘要: Pharmaceutical drugs are necessary to cure or slow down the progression of diseases. The promising chemical and biological candidates that go through drug development process evaluated firs...
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Nico Scheer, Ian D. Wilson, A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity. Drug Discovery Today. ,vol. 21, pp. 250- 263 ,(2016) , 10.1016/J.DRUDIS.2015.09.002
J. Fred Pritchard, Malle Jurima-Romet, Mark L. J. Reimer, Elisabeth Mortimer, Brenda Rolfe, Mitchell N. Cayen, Making Better Drugs: Decision Gates in Non-Clinical Drug Development Nature Reviews Drug Discovery. ,vol. 2, pp. 542- 553 ,(2003) , 10.1038/NRD1131
Ilka Maschmeyer, Alexandra K. Lorenz, Katharina Schimek, Tobias Hasenberg, Anja P. Ramme, Juliane Hübner, Marcus Lindner, Christopher Drewell, Sophie Bauer, Alexander Thomas, Naomia Sisoli Sambo, Frank Sonntag, Roland Lauster, Uwe Marx, A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents Lab on a Chip. ,vol. 15, pp. 2688- 2699 ,(2015) , 10.1039/C5LC00392J
Ilka Maschmeyer, Tobias Hasenberg, Annika Jaenicke, Marcus Lindner, Alexandra Katharina Lorenz, Julie Zech, Leif-Alexander Garbe, Frank Sonntag, Patrick Hayden, Seyoum Ayehunie, Roland Lauster, Uwe Marx, Eva-Maria Materne, Chip-based human liver-intestine and liver-skin co-cultures--A first step toward systemic repeated dose substance testing in vitro. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 95, pp. 77- 87 ,(2015) , 10.1016/J.EJPB.2015.03.002
Eva-Maria Materne, Anja Patricia Ramme, Ana Paula Terrasso, Margarida Serra, Paula Marques Alves, Catarina Brito, Dmitry A. Sakharov, Alexander G. Tonevitsky, Roland Lauster, Uwe Marx, A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing Journal of Biotechnology. ,vol. 205, pp. 36- 46 ,(2015) , 10.1016/J.JBIOTEC.2015.02.002
Eric W. Esch, Anthony Bahinski, Dongeun Huh, Organs-on-chips at the frontiers of drug discovery Nature Reviews Drug Discovery. ,vol. 14, pp. 248- 260 ,(2015) , 10.1038/NRD4539
Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen, Jouko Savolainen, Prodrugs: design and clinical applications Nature Reviews Drug Discovery. ,vol. 7, pp. 255- 270 ,(2008) , 10.1038/NRD2468
Xi-Ling Jiang, Frank J. Gonzalez, Ai-Ming Yu, Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. Drug Metabolism Reviews. ,vol. 43, pp. 27- 40 ,(2011) , 10.3109/03602532.2010.512294
Brenton R. Ware, Dustin R. Berger, Salman R. Khetani, Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes Toxicological Sciences. ,vol. 145, pp. 252- 262 ,(2015) , 10.1093/TOXSCI/KFV048
Connie Cheung, Ai-Ming Yu, Jerrold M. Ward, Kristopher W. Krausz, Taro E. Akiyama, Lionel Feigenbaum, Frank J. Gonzalez, The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity. Drug Metabolism and Disposition. ,vol. 33, pp. 449- 457 ,(2005) , 10.1124/DMD.104.002402