A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.

摘要: Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity mice engrafted with human hepatocytes are emerging promising vivo models an improved prediction of the pharmacokinetic, drug-drug interaction safety characteristics compounds humans. The specific advantages disadvantages these should be carefully considered when using them studies discovery development. Here, overview on corresponding chimeric liver mouse described to date is provided illustrated examples their utility studies. We compare strength weaknesses two different approaches, give guidance selection appropriate model various applications discuss future trends perspectives.