Anti-inflammatory Effects of Compounds from Polygonum odoratum.

摘要: Polygonum odoratum is an edible plant traditionally used as antidiabetic, antimicrobial, anti-inflammatory, and antitumor agent in Asia. The aim of the study was to evaluate anti-inflammatory effect P. isolation characterization its main fractions. Extracts aerial parts were tested for activity indicated by a change cytokine secretion lipopolysaccharide-stimulated macrophages. After separation extract reversed-phase high-performance liquid chromatography, fractions determined. Furthermore, two identified nuclear magnetic resonance spectroscopy ((1)H- (13)C-NMR). ethanolic significantly reduced IL-6 (IC50 25 pg/mL). (5 7) decreased production with IC(50) 102 μM (5) 77 (7), respectively, scutellarein-7-glucoside quercitrin (7). Since inflammation plays major role various diseases high prevalence globally, it may be importance that constituents can either alternative or complementary treatment. Additionally, both are glycosides their enhanced tremendously deglycosylation gut microbiota.