Flavonoid Glycosides of Polygonum capitatum Protect against Inflammation Associated with Helicobacter pylori Infection

摘要: The antibacterial and anti-inflammatory activities, protective effects of extracts (flavonoid glycosides) Polygonum capitatum were investigated to detect the evidence for utilization herb in clinical therapy gastritis caused by H. pylori. A mouse model was established using According treating methods, mice random assigned into a group (MG group), triple antibiotics (TG group, clarithromycin, omeprazole amoxicillin), low/middle/high concentrations flavonoid glycosides groups (LF, MF HF groups) amoxicillin (LFA, MFA HFA groups). with pathogen-free regarded as control (CG group). eradicate rates pylori 100%, 93%, 89% TG, groups. serum levels IFN-gamma gastrin higher MG than those from all other (P < 0.05). reduced significantly LF, 0.05) while little changes observed LFA, In contrast, IL-4 lower CG compared (P<0.05). increased found pathological scores, showed better protection gastric injuries combination glycoside results suggested that has repairing functions injuries. suggest plant can treat protect against should be developed potential drug