Manufacturing Cell Therapies Using Engineered Biomaterials
作者： Amr A. Abdeen , Krishanu Saha
DOI: 10.1016/J.TIBTECH.2017.06.008
关键词:
摘要: Emerging manufacturing processes to generate regenerative advanced therapies can involve extensive genomic and/or epigenomic manipulation of autologous or allogeneic cells. These cell engineering need be carefully controlled and standardized maximize safety efficacy in clinical trials. Engineered biomaterials with smart tunable properties offer an intriguing tool provide deliver cues retain stemness, direct differentiation, promote reprogramming, manipulate the genome, select functional phenotypes. This review discusses use engineered control human manufacturing. Future work exploiting has potential that produce cells well-defined critical quality attributes appropriate for testing.
sci-hub.se 参考文章(107)
Junmin Lee, Amr A. Abdeen, Xin Tang, Taher A. Saif, Kristopher A. Kilian, Geometric guidance of integrin mediated traction stress during stem cell differentiation Biomaterials. ,vol. 69, pp. 174- 183 ,(2015) , 10.1016/J.BIOMATERIALS.2015.08.005
Ty Harkness, Jason D. McNulty, Ryan Prestil, Stephanie K. Seymour, Tyler Klann, Michael Murrell, Randolph S. Ashton, Krishanu Saha, High-content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics Biotechnology Journal. ,vol. 10, pp. 1555- 1567 ,(2015) , 10.1002/BIOT.201400756
Patricia Rojas-Ríos, Acaimo González-Reyes, Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair Stem Cells. ,vol. 32, pp. 852- 859 ,(2014) , 10.1002/STEM.1621
Alan Trounson, Courtney McDonald, Stem Cell Therapies in Clinical Trials: Progress and Challenges Cell Stem Cell. ,vol. 17, pp. 11- 22 ,(2015) , 10.1016/J.STEM.2015.06.007
Kevin M. Beussman, Marita L. Rodriguez, Andrea Leonard, Nikita Taparia, Curtis R. Thompson, Nathan J. Sniadecki, Micropost arrays for measuring stem cell-derived cardiomyocyte contractility. Methods. ,vol. 94, pp. 43- 50 ,(2016) , 10.1016/J.YMETH.2015.09.005
Chunxiao Qi, Xiaojun Yan, Chenyu Huang, Alexander Melerzanov, Yanan Du, Biomaterials as carrier, barrier and reactor for cell-based regenerative medicine Protein & Cell. ,vol. 6, pp. 638- 653 ,(2015) , 10.1007/S13238-015-0179-8
Laurent Poirot, Brian Philip, Cécile Schiffer-Mannioui, Diane Le Clerre, Isabelle Chion-Sotinel, Sophie Derniame, Pierrick Potrel, Cécile Bas, Laetitia Lemaire, Roman Galetto, Céline Lebuhotel, Justin Eyquem, Gordon Weng-Kit Cheung, Aymeric Duclert, Agnès Gouble, Sylvain Arnould, Karl Peggs, Martin Pule, Andrew M. Scharenberg, Julianne Smith, Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies Cancer Research. ,vol. 75, pp. 3853- 3864 ,(2015) , 10.1158/0008-5472.CAN-14-3321
Naomi D’souza, Filippo Rossignoli, Giulia Golinelli, Giulia Grisendi, Carlotta Spano, Olivia Candini, Satoru Osturu, Fabio Catani, Paolo Paolucci, Edwin M. Horwitz, Massimo Dominici, Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies BMC Medicine. ,vol. 13, pp. 186- 186 ,(2015) , 10.1186/S12916-015-0426-0
Mohammad Ariful Islam, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter, Jinjun Shi, Biomaterials for mRNA delivery Biomaterials Science. ,vol. 3, pp. 1519- 1533 ,(2015) , 10.1039/C5BM00198F
William L. Murphy, Todd C. McDevitt, Adam J. Engler, Materials as stem cell regulators Nature Materials. ,vol. 13, pp. 547- 557 ,(2014) , 10.1038/NMAT3937