Chronic immune thrombocytopenic purpura--immunological analyses of a patient pre- and post-HIV seroconversion.

摘要: A seven year follow-up of immune parameters is reported for a patient with chronic thrombocytopenic purpura (ITP) pre and post human immunodeficiency virus (HIV) seroconversion. Therapies such as intravenous IgG, prednison, vincristine, or Ciclosporin had no clear-cut beneficial effect on platelet counts. long-term normalization counts was achieved by splenectomy. At splenectomy the seropositive HIV, most likely transmitted blood products received half prior to laparatomy. Mean plasma levels second component complement, C2, were normal values within lowest range HIV Nevertheless, T cell-dependent B cell response which dependent activation C3 via classical pathway normal: Western blot analysis total IgG subclass responses individual antigens proved be unimpaired.