Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
作者： Christine E Canman , Dae-Sik Lim , Karlene A Cimprich , Yoichi Taya , Katsuyuki Tamai
DOI: 10.1126/SCIENCE.281.5383.1677
关键词:
摘要: The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. gene product mutated ataxia telangiectasia, ATM, acts upstream of a signal transduction pathway initiated by ionizing radiation. Immunoprecipitated ATM had intrinsic kinase activity manganese-dependent manner. Ionizing radiation, but not ultraviolet rapidly enhanced this p53-directed endogenous ATM. These observations, along with the fact that phosphorylation radiation reduced telangiectasia cells, suggest phosphorylates vivo.
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