Lack of Rapid Development of Opioid Tolerance During Alfentanil and Remifentanil Infusions for Postoperative Pain

摘要: Studies in animals and volunteers have suggested the development of acute tolerance to opioid analgesics. In this article, we present data from patients who regulated their own target-controlled infusions alfentanil remifentanil provide analgesia immediate postoperative period. Fifty-one received for 24 h after cardiac surgery, 30 6 orthopedic surgery. Satisfactory analgesia, defined as a rating ≤3 on an 11-point visual analog scale, was obtained by each type The target concentrations opioids required produce cumulative doses administered over course clinical observation suggest there no analgesic effects opioids. requirements both drugs individual had large variation (>200%). We conclude that our results may indicate absence analgesia. Nonetheless, show requirement these rapidly acting is qualitatively similar other dosage escalation does not occur. Implications: analgesics has been based experimental studies volunteers. Our report self-controlled using provides evidence