Role of CD4 and CD8 T-lymphocytes, B-lymphocytes and Natural Killer cells in the prediction of radiation-induced late toxicity in cervical cancer patients.
作者： Elisa Bordón , Luis Alberto Henríquez-Hernández , Pedro Carlos Lara , Beatriz Pinar , Carlos Rodríguez-Gallego
DOI: 10.3109/09553002.2010.537433
关键词:
摘要: Purpose: To analyse the role of in vitro radio-induced apoptosis lymphocyte subpopulations as predictive test for late effects cervical cancer patients treated with radiotherapy.Methods and materials: Ninety-four consecutive four healthy controls were included study. Toxicity was evaluated using Late Effects Normal Tissue-Subjective, Objective, Management, Analytic (LENT-SOMA) scale. Peripheral blood isolated irradiated at 0, 1, 2 8 Gy, then collected 24, 48 72 h after irradiation. Apoptosis measured by flow cytometry.Results: Radiation-induced increased radiation dose time incubation, data fitted to a semi-logarithmic model defined two constants: α (percentage spontaneous cell death) β death induced determined dose). Higher values cytotoxic T-lymphocytes (CD8) bone cells (B-lymphocytes) observed low bowel toxicity (hazar...
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