The extracellular matrix in hepatic regeneration.

摘要: After partial hepatectomy, as a consequence of hepatocyte proliferation, cell clusters containing 10-14 hepatocytes are formed. These devoid sinusoids and extracellular matrix; therefore, many two to three cells removed from the vascular spaces. Four days after Ito send delicate processes between in clusters. This "invasion" coincides with activation genes encoding for several laminin chains. The penetration into is followed by fenestrated endothelial cells, this manner normal relationship restored. As soon structure reestablished, turned off. chain events similar one taking place during hepatogenesis when continuous capillaries converted sinusoids. similarity regeneration suggests that secreted chains may be signals ...