Surgical site infection prevention following total hip arthroplasty in Australia: A cost-effectiveness analysis

摘要: Background Surgical site infection (SSI) is associated with substantial costs for health services, reduced quality of life, and functional outcomes. The aim this study was to evaluate the cost-effectiveness strategies claiming reduce risk SSI in hip arthroplasty Australia. Methods Baseline use antibiotic prophylaxis (AP) compared no (no AP), antibiotic-impregnated cement (AP + ABC), laminar air operating rooms LOR). A Markov model used simulate long-term cost outcomes a hypothetical cohort 30,000 total patients from services perspective. Model parameters were informed by best available evidence. Uncertainty explored probabilistic sensitivity scenario analyses. Results Stopping routine AP resulted over Australian dollars (AUD) $1.5 million extra loss 163 quality-adjusted life years (QALYs). Using addition ABC) generated an 32 QALYs while saving AUD $123,000. combined LOR) $4.59 increase 127 lost baseline comparator. Conclusion Preventing deep has shown improve among hospitalized patients, save lives, enhance resource allocation. Based on evidence, not recommended.