Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system
作者： Noriko Satoh , Yoshihiro Ogawa , Goro Katsuura , Yoshito Numata , Hiroaki Masuzaki
DOI: 10.1016/S0304-3940(98)00401-7
关键词:
摘要: Leptin is an adipocyte-derived blood-borne satiety factor that decreases food intake and increases energy expenditure, thereby leading to a substantial decrease in body weight. To explore the possible roles of hypothalamic melanocortin system leptin action, we examined effects intracerebroventricular (ICV) injection with or without SHU9119, potent antagonist α-melanocyte stimulating hormone, on intake, weight, mitochondrial uncoupling protein-1 (UCP-1) mRNA expression brown adipose tissue (BAT) rats. A single ICV decreased cumulative weight gain, increased UCP-1 during 3 h at onset dark phase. Inhibition change was reversed by co-injection SHU9119 dose-dependent manner. Co-injection also inhibited completely leptin-induced increase BAT. Treatment alone did not affect The present study provides evidence plays central role both effect sympathetic activation leptin.
elsevier.com
sci-hub.se 参考文章(21)
F Bouillaud, J Weissenbach, D Ricquier, Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein. Journal of Biological Chemistry. ,vol. 261, pp. 1487- 1490 ,(1986) , 10.1016/S0021-9258(17)35962-8
P. J. Scarpace, M. Matheny, B. H. Pollock, N. Tumer, Leptin increases uncoupling protein expression and energy expenditure American Journal of Physiology-endocrinology and Metabolism. ,vol. 273, ,(1997) , 10.1152/AJPENDO.1997.273.1.E226
C M Kotz, M K Grace, J Briggs, A S Levine, C J Billington, Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat. Neural site of action. Journal of Clinical Investigation. ,vol. 96, pp. 163- 170 ,(1995) , 10.1172/JCI118017
Robert A. Kesterson, Dennis Huszar, Catherine A. Lynch, Richard B. Simerly, Roger D. Cone, Induction of Neuropeptide Y Gene Expression in the Dorsal Medial Hypothalamic Nucleus in Two Models of the Agouti Obesity Syndrome Molecular Endocrinology. ,vol. 11, pp. 630- 637 ,(1997) , 10.1210/MEND.11.5.9921
Jay C. Erickson, Kathy E. Clegg, Richard D. Palmiter, Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y Nature. ,vol. 381, pp. 415- 418 ,(1996) , 10.1038/381415A0
Dennis Huszar, Catherine A Lynch, Victoria Fairchild-Huntress, Judy H Dunmore, Qing Fang, Lucy R Berkemeier, Wei Gu, Robert A Kesterson, Bruce A Boston, Roger D Cone, Francoise J Smith, L.Arthur Campfield, Paul Burn, Frank Lee, Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell. ,vol. 88, pp. 131- 141 ,(1997) , 10.1016/S0092-8674(00)81865-6
Michael W Schwartz, Randy J Seeley, Stephen C Woods, David S Weigle, L Arthur Campfield, Paul Burn, Denis G Baskin, Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus Diabetes. ,vol. 46, pp. 2119- 2123 ,(1997) , 10.2337/DIAB.46.12.2119
Kathleen G Mountjoy, Jencia Wong, Obesity, Diabetes and Functions for Proopiomelanocortin-derived Peptides Molecular and Cellular Endocrinology. ,vol. 128, pp. 171- 177 ,(1997) , 10.1016/S0303-7207(96)04017-8
Melissa Graham, John R. Shutter, Ulla Sarmiento, lldiko Sarosi, Kevin L Stark, Overexpression of Agrt leads to obesity in transgenic mice. Nature Genetics. ,vol. 17, pp. 273- 274 ,(1997) , 10.1038/NG1197-273
Wei Fan, Bruce A. Boston, Robert A. Kesterson, Victor J. Hruby, Roger D. Cone, Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature. ,vol. 385, pp. 165- 168 ,(1997) , 10.1038/385165A0