G-Quadruplex-Mediated Molecular Switching of Self-Assembled 3D DNA Nanocages

作者: Dick Yan Tam , Hoi Man Leung , Miu Shan Chan , Pik Kwan Lo

DOI: 10.1002/CNMA.201700172

关键词:

摘要: We have demonstrated a strategy to reversibly extend and contract 3D DNA nanocages based on stimuli-responsive G-rich strand as scaffold. The contraction extension of nanocage would be regulated by formation deformation G-quadruplex in the presence K+ ions chelating agents respectively. As opposed single human telomeric strands (HTL), advantage integrating three HTLs into structure for molecular switching is that multi oligonucleotide sequences which extensively exist living environments play important roles biological mechanisms, can simultaneously introduced self-assembled system with versatile functionalities while conformational changes rationally designed controlled different stimuli/targets. In addition, compared strands, act horseradish peroxidase mimicking DNAzymes colorimetric detection monitoring cholesterol high stability toward nuclease blood serum degradations. Overall, this first example facile construction nanostructures contractile, reversible, catalytic features assembly disassembly G-quadruplexes. This work offers new platform manipulation nanoscale step forward obtaining nanomaterials reactivity functionalities.

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