Medullary pathway of the Bezold-Jarisch reflex in the rat.
作者： A. J. Verberne , P. G. Guyenet
DOI: 10.1152/AJPREGU.1992.263.6.R1195
关键词:
摘要: The central pathway mediating the Bezold-Jarisch reflex elicited by jugular vein injection of serotonin (5-HT) and phenyl biguanide (PBG) was studied in halothane-anesthetized, paralyzed rats. 5-HT PBG produced hypotension inhibition lumbar sympathetic discharge often preceded sympathoexcitation. Bezold-Jarish blocked bilateral kynurenic acid (KYN; glutamate antagonist, 1.25 nmol/side) microinjection into solitary tract nucleus. Bilateral KYN caudal ventrolateral medulla (5 also reflex. bicuculline methiodide (BIC; 100 pmol/side) rostral (RVL) reduced depressor sympathoinhibitory components enhanced an excitatory component. Blockade or attenuation always associated with a concomitant blockade arterial baroreflex. RVL barosensitive neurons (n = 61) were inhibited (> 60% reduction firing) 5-HT. Iontophoretic application BIC 11 cells), but not strychnine (glycine antagonist), PBG. component may use similar to that
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