Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms.

摘要: Huntington's disease is a progressive, degenerative characterized by abnormal body movements called chorea, and reduction of various mental abilities. 3-Nitropropionic acid, an inhibitor complex II the electron transport chain, causes disease-like symptoms in rodents. Recently, it has been reported that oxidative stress, which one pathological hallmarks neurodegenerative disorders, also plays important role pathogenesis disease. The present study was designed to investigate effects resveratrol, antioxidant with cyclooxygenase I inhibitory activity, 3-nitropropionic acid-induced model Intraperitoneal administration acid (20 mg/kg for 4 days) caused significant loss weight, decline motor function (locomotor movement pattern vacuous chewing movements) poor retention memory. Repeated treatment resveratrol (5 10 mg/kg, orally), once daily period 8 days beginning prior administration, significantly improved cognitive impairment. Biochemical analysis revealed systemic increased lipid peroxidation, nitrite levels, depleted reduced glutathione decreased succinate dehydrogenase activity brains rats. results indicate orally) reversed impairment, beneficial might be attributed its activity.