Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease.

摘要: To study the possible role of isoenzymes cyclooxygenase COX-1 and COX-2 in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model Parkinson's disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, comparison with meloxicam, preferential inhibitor. As markers protection determined effects on MPTP-induced striatal dopamine depletion, locomotor activity, cell loss, tyrosine hydroxylase immunoreactivity (TH-IR) substantia nigra pars compacta. Male C57BL/6 mice (n = 82) were treated single dose acid (10, 50, 100 mg/kg i.p.) or meloxicam (2, 7.5, 50 immediately prior to administration (30 s.c.) saline. After 7 days sacrificed analyze metabolite levels. Nigral sections processed for Nissl-staining TH-IR. In saline-treated control group levels reduced 15.9% values. Dopamine depletion was significantly attenuated values 37.1 38.6% saline by (50 mg/kg) 36 40% (7.5 mg/kg), respectively. decrease activity meloxicam. Remarkably, TH-IR as well loss nigral neurons nearly completely prevented (100 mg/kg). conclusion, inhibition either preferentially provided clear neuroprotection against MPTP-toxicity Synapse 39:167–174, 2001. © 2001 Wiley-Liss, Inc.