Dose invasive apocrine adenocarcinoma has worse prognosis than invasive ductal carcinoma of breast: evidence from SEER database.

摘要: // Ning Zhang 1 , Hanwen Tong Chen Qifeng Yang 1, 2 Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, 250012, Province, People’s Republic China Pathology Tissue Bank, Correspondence to: Yang, email: qifengy_sdu@163.com Keywords: apocrine adenocarcinoma, breast cancer, surveillance, epidemiology and end result (SEER), prognosis Received: January 09, 2017      Accepted: February 13, Published: 21, 2017 ABSTRACT Background: Invasive adenocarcinoma (AAC) is a rare histopathological subtype carcinomas. We aim to investigate the different characteristics prognostic outcomes between AAC invasive ductal carcinoma (IDC) cancer. Results: patients presented with older ages, more aggressive behaviors, lower ER PR proportions, higher HER2 amplification rates less application breast-conserving therapy adjuvant chemotherapy compared IDC patients. Long-term OS DSS were both worse in ACC ( p = 0.006, 0.012 respectively) than by Kaplan-Meier analysis. However, no significant difference was detected 0.181) 0.116) matched two histological subtypes. Further subgroup analysis indicated that AJCC stage, status, status may be principal confounders for prognosis. Materials Methods: With accession Surveillance, Epidemiology End Result (SEER) database, total 260,596 met eligibility criteria. Clinicopathological groups using Chi-square test. Univariate multivariate analyses applied evaluate overall survival (OS) disease-specific (DSS). Subgroup summarized hazard ratio (HR) versus forest plot. Conclusions: had unique clinicopathological it tended type IDC. diminished after matching demographic factors. Deeper insights into are need contribute individualized tailored therapy, which thereby improve clinical management outcomes.