Diabetes triggers the loss of tooth structure associated to radiographical and histological dental changes and its evolution to progressive pulp and periapical lesions in rats

摘要: Abstract Objectives The aim of this study was to evaluate the putative influence diabetes without metabolic control in loss tooth structure as well histological changes dentin and pulp tissue rats. Design Diabetes induced Wistar rats ( n  = 25) by intravenous administration alloxan (42 mg/kg). Diabetic non-diabetic were evaluated at 1, 3, 6, 9 12 months follow-up. In order presence progression dental caries periapical lesions, hemimandibles removed submitted radiographical, histological, morphometrical procedures. Results Dental detected after radiographical evaluations diabetic group from third month onset, increasing gradually frequency severity periods. pulps also presented significant reduction volume density collagen fibers fibroblasts month, parallel with a trend towards increase inflammatory cells density. generalized necrosis 6 induction. Moreover, lesions not group, while these observed all 9, Conclusions Uncontrolled seems trigger structure, associated mediates its evolution progressive severe Therefore, may be considered very important risk factor regarding alterations pulp, development caries, lesions.