Tachykinin antagonists inhibit the morphine withdrawal response in guinea-pigs
作者： P.A. Johnston , LorisA. Chahl
DOI: 10.1007/BF00251127
关键词:
摘要: This study was an investigation of the effects tachykinin antagonists, spantide and (d-Pro4, d-Trp7, 9, 10)substance P 4-11, injected intracerebroventricularly (ICV), on locomotor behavioural responses guinea-pigs to substance (SP) ICV naloxone-induced morphine withdrawal. SP, 50 nmol, produced increased activity behaviour that mimicked response induced by injection naloxone hydrochloride, 15 mg/kg, in treated 2 h previously with sulphate, mg/kg. Spantide or 10)SP4-11, 10 reduced SP The results support suggestion a related might be mediator opioid withdrawal central nervous system as has been proposed for enteric system.
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