Increased plasma catecholamines and locomotor activity induced by centrally administered substance P in guinea-pigs.

摘要: The effects on locomotor activity and plasma catecholamines of substance P, 0.5 nmol, injected into each lateral ventricle (i.c.v.), or 1 the cisterna magna conscious guinea-pigs, were investigated. Locomotor was measured in cages fitted with an infra-red photocell detector, catecholamines, by HPLC electrochemical detection. Substance given intraventricularly magna, produced increased a pattern behavioural which mimicked opiate withdrawal response, found previous studies this species. Levels NA AD also significantly elevated after injection P. These P relatively long-lasting, since they present up to hr injection. results show that centrally administered guinea-pigs are similar those rats. Furthermore, support suggestion might be mediator response central nervous system as has been proposed for enteric system.