Effects of a novel potential antidepressant on the behavior and cortisol levels of isolated guinea pig pups.
作者： Michael B Hennessy , Lisa Pitstick , Shonagh O'Leary , Deborah S Maken , Antonio J Farré
DOI: 10.1016/S0091-3057(01)00571-8
关键词:
摘要: Abstract A novel, potential antidepressant, E-6006 citrate (E-6039), dose-dependently reduced the vocalizations emitted by isolated guinea pig pups. The (+)-E-6006, but not (−)-E-6006, enantiomer also vocalizing. There were no reliable effects of E-6039 on locomotor activity, crouching, or other behavioral measures, both and (+)-E-6006 elevated plasma cortisol levels during isolation. contrasting are discussed in terms E-6039's putative ability to inhibit release substance P. reduction pups corroborates positive results with this drug antidepressant screens utilizing mice rats, provides further support for as an compound.
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